Indy, short for I'm not dead yet, is a gene of the model organism, the fruitfly Drosophila melanogaster. Mutant versions of this gene doubles the fruitflies' average life span (this is subject to controversy).[1] Its name originates from a repeated comic line in Monty Python and the Holy Grail[2]
In a Yale University School of Medicine study by lead author and Howard Hughes Medical Institute investigator Gerald Shulman, the George R. Cowgill Professor of Physiological Chemistry, Medicine, and Cellular and Molecular Biology, reduced expression of this gene in Drosophila melanogaster flies and C. elegans worms modeled the effects on obesity and diabetes of caloric reduction in primates such as humans.[3]